Изворни код странице Taksan 10b-hidroksilaza

{{Infobox Enzim-lat
| Name = Taksan 10b-hidroksilaza
| EC_number = 1.14.13.76
| CAS_number = 337514-75-7
| IUBMB_EC_number = 1/14/13/76
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Taksan 10b-hidroksilaza''' ({{EC broj-lat|1.14.13.76}}, ''taksanska 10b-hidroksilaza'') je [[enzim]] sa sistematskim imenom ''taksa-4(20),11-dien-5alfa-il acetat,-{NADPH}-:kiseonik oksidoreduktaza (10beta-hidroksilacija)''.<ref>{{cite journal | title = Taxol biosynthesis: differential transformations of taxadien-5&alpha;-ol and its acetate ester by cytochrome ''P''<small><sub>450</sub></small> hydroxylases from ''Taxus'' suspension cells |author = Wheeler, A.L., Long, R.M., Ketchum, R.E., Rithner, C.D., Williams, R.M. and Croteau, R. |journal = Arch. Biochem. Biophys. |date = 2001 |volume = 390 |pages = 265-78 |pmid = 11396929}}</ref><ref>{{cite journal | title = Taxol biosynthesis: taxane 13 &alpha;-hydroxylase is a cytochrome ''P''<small><sub>450</sub></small>-dependent monooxygenase |author = Jennewein, S., Rithner, C.D., Williams, R.M. and Croteau, R.B. |journal = Proc. Natl. Acad. Sci. USA |date = 2001 |volume = 98 |pages = 13595-13560 |pmid = 11707604}}</ref><ref>{{cite journal | title = Molecular cloning of a cytochrome ''P''<small><sub>450</sub></small> taxane 10&beta;-hydroxylase cDNA from ''Taxus'' and functional expression in yeast |author = Schoendorf, A., Rithner, C.D., Williams, R.M. and Croteau, R.B. |journal = Proc. Natl. Acad. Sci. USA |date = 2001 |volume = 98 |pages = 1501-1506 |pmid = 11171980}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: taksa-4(20),11-dien-5alfa-il acetat + -{NADPH + H}-<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 10beta-hidroksitaksa-4(20),11-dien-5alfa-il acetat + -{NADP}-<sup>+</sup> +-{H}-<sub>2</sub>O

Ovaj mikrozomalni citohrom-P450-zavisni enzim učestvuje u biosinteza diterpenoidnog antineoplastičnog leka [[taksol]]a (paklitaksela).

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|Taxane+10beta-hydroxylase}}

{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

{{normativna kontrola}}

[[Категорија:ЕЦ 1.14.13]]