Изворни код странице RRNK mala podjedinica pseudouridinske metiltransferaze Nep1

{{Infobox Enzim-lat
| Name = rRNK mala podjedinica pseudouridinske metiltransferaze -{Nep1}-
| EC_number = 2.1.1.260
| CAS_number = 
| IUBMB_EC_number = 2/1/1/260
| GO_code = 
| image = 
| width = 
| caption =
}}
'''rRNK mala podjedinica pseudouridinske metiltransferaze -{Nep1}-''' ({{EC broj-lat|2.1.1.260}}, -{''Nep1''}-, ''nukleolarni esencijalni protein 1'') je [[enzim]] sa sistematskim imenom ''-{S}--adenozil--{L}--metionin:18-{S}- rRNK (pseudouridin<sup>1191</sup>--{N}-<sup>1</sup>)-metiltransferaza''.<ref>{{cite journal | title = The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site |author = Taylor, A.B., Meyer, B., Leal, B.Z., K&ouml;tter, P., Schirf, V., Demeler, B., Hart, P.J., Entian, K.-D. and W&ouml;hnert, J. |journal = Nucleic Acids Res. |date = 2008 |volume = 36 |pages = 1542-1554 |pmid = 18208838}}</ref><ref>{{cite journal | title = The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-''N''<small><sup>1</sup></small>-specific methyltransferase |author = Wurm, J.P., Meyer, B., Bahr, U., Held, M., Frolow, O., K&ouml;tter, P., Engels, J.W., Heckel, A., Karas, M., Entian, K.-D. and W&ouml;hnert, J. |journal = Nucleic Acids Res. |date = 2010 |volume = 38 |pages = 2387-2398 |pmid = 20047967}}</ref><ref>{{cite journal | title = The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of &Psi;<small><sup>1191</sup></small> in yeast 18S rRNA |author = Meyer, B., Wurm, J.P., K&ouml;tter, P., Leisegang, M.S., Schilling, V., Buchhaupt, M., Held, M., Bahr, U., Karas, M., Heckel, A., Bohnsack, M.T., W&ouml;hnert, J. and Entian, K.-D. |journal = Nucleic Acids Res. |date = 2011 |volume = 39 |pages = 1526-1537 |pmid = 20972225}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: -{S}--adenozil--{L}--metionin + pseudouridin<sup>1191</sup> u kvašćanoj 18-{S}- rRNK <math>\rightleftharpoons</math> -{S}--adenozil--{L}--homocistein + -{N}-<sup>1</sup>-metilpseudouridin<sup>1191</sup> u kvašćanoj 18-{S}- rRNK

Ovaj enzim se javlja kod prokariota i eukariota. On specifično prepoznaje pseudouridinske ostatke (Psi) u malim podjedinicama ribozomalne RNK na bazi lokalne RNK strukture.

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|RRNA+small+subunit+pseudouridine+methyltransferase+Nep1}}

{{Jednougljenične transferaze-lat}}
{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

{{normativna kontrola}}

[[Категорија:ЕЦ 2.1.1]]