Изворни код странице Metilisani-DNK—(protein)-cistein S-metiltransferaza

{{Infobox Enzim-lat
| Name = Metilisani-DNK—(protein)-cistein -{S}--metiltransferaza
| EC_number = 2.1.1.63
| CAS_number = 77271-19-3
| IUBMB_EC_number = 2/1/1/63
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Metilisani-DNK—(protein)-cistein -{S}--metiltransferaza''' ({{EC broj-lat|2.1.1.63}}, ''Methylated-DNA---(protein)-cysteine -{S}--methyltransferase'') je [[enzim]] sa sistematskim imenom ''DNK-6-O-metilguanin:(protein)--{L}--cistein -{S}--metiltransferaza''.<ref>{{cite journal | title = Demethylation of ''O''<sup>6</sup>-methylguanine in a synthetic DNA polymer by an inducible activity in ''Escherichia coli'' |author = Foote, R.S., Mitra, S. and Pal, B.C. |journal = Biochem. Biophys. Res. Commun. |date = 1980 |volume = 97 |pages = 654-659 |pmid = 7008792}}</ref><ref>{{cite journal | title = Repair of alkylated DNA in ''Escherichia coli''. Methyl group transfer from ''O''<sup>6</sup>-methylguanine to a protein cysteine residue |author1=Olsson, M.  |author2=Lindehl, T.  |lastauthoramp=yes |journal = J. Biol. Chem. |date = 1980 |volume = 255 |pages = 10569-10571 |pmid = 7000780}}</ref><ref>{{cite journal | title = Repair of DNA containing ''O''<sup>6</sup>-alkylguanine | url = https://archive.org/details/sim_faseb-journal_1992-03_6_6/page/2302 |author1=Pegg, A.E.  |author2=Byers, T.L.  |lastauthoramp=yes |journal = FASEB J. |date = 1992 |volume = 6 |pages = 2302-2310 |pmid = 1544541}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: DNK (koja sadrži 6-O-metilguanin) + protein -{L}--[[cistein]] <math>\rightleftharpoons</math> DNK (bez 6-O-metilguanina) + protein -{S}--metil--{L}--cistein

Ovaj protein učestvuje u popravci alkilisanog DNK. On deluje na alkilisani DNK (cf. [[EC 3.2.2.20]], DNK-3-metiladenin glikozidaza I i [[EC 3.2.2.21]], DNK-3-metiladenin glikozidaza II).

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|Methylated-DNA—(protein)-cysteine+S-methyltransferase}}

{{Jednougljenične transferaze-lat}}
{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

{{normativna kontrola}}

[[Категорија:ЕЦ 2.1.1]]