Изворни код странице Kvorum-sensing N-acil-homoserinska laktonaza

{{Infobox Enzim-lat
| Name = Kvorum-sensing -{N}--acil-homoserinska laktonaza
| EC_number = 3.1.1.81
| CAS_number = 389867-43-0
| IUBMB_EC_number = 3/1/1/81
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Kvorum-sensing -{N}--acil-homoserinska laktonaza''' ({{EC broj-lat|3.1.1.81}}, ''acil homoserin degradirajući enzim'', ''acil-homoserin laktonska acilaza'', ''AHL laktonaza'', ''AHL-degradirajući enzim'', ''AHL-inaktivirajući enzim'', ''AHLaza'', ''AhlD'', ''AhlK'', ''AiiA'', ''AiiA laktonaza'', ''AiiA-sličan protein'', ''AiiB'', ''AiiC'', ''AttM'', ''delaktonaza'', ''laktonazi sličan enzim'', ''-{N}--acil homoserin laktonaza'', ''-{N}--acil homoserin laktonska hidrolaza'', ''-{N}--acil-homoserin laktonska laktonaza'', ''-{N}--acil-L-homoserin laktonska hidrolaza'', ''kvorum-sensing laktonaza'', ''kvorum-sensing N-acil homoserin laktonska hidrolaza'') je [[enzim]] sa sistematskim imenom ''-{N}--acil--{L}--homoserin-lakton laktonohidrolaza''.<ref>{{cite journal | title = The quorum-quenching lactonase from ''Bacillus thuringiensis'' is a metalloprotein |author = Thomas, P.W., Stone, E.M., Costello, A.L., Tierney, D.L. and Fast, W. |journal = Biochemistry |date = 2005 |volume = 44 |pages = 7559-7569 |pmid = 15895999}}</ref><ref>{{cite journal | title = Identification of quorum-quenching ''N''-acyl homoserine lactonases from ''Bacillus'' species | url = https://archive.org/details/sim_applied-and-environmental-microbiology_2002-04_68_4/page/1754 |author = Dong, Y.H., Gusti, A.R., Zhang, Q., Xu, J.L. and Zhang, L.H. |journal = Appl. Environ. Microbiol. |date = 2002 |volume = 68 |pages = 1754-1759 |pmid = 11916693}}</ref><ref>{{cite journal | title = Specificity and enzyme kinetics of the quorum-quenching ''N''-acyl homoserine lactone lactonase (AHL-lactonase) |author = Wang, L.H., Weng, L.X., Dong, Y.H. and Zhang, L.H. |journal = J. Biol. Chem. |date = 2004 |volume = 279 |pages = 13645-13651 |pmid = 14734559}}</ref><ref>{{cite journal | title = AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of ''Erwinia carotovora'' |author = Dong, Y.H., Xu, J.L., Li, X.Z. and Zhang, L.H. |journal = Proc. Natl. Acad. Sci. USA |date = 2000 |volume = 97 |pages = 3526-3531 |pmid = 10716724}}</ref><ref>{{cite journal | title = Quenching quorum-sensing-dependent bacterial infection by an ''N''-acyl homoserine lactonase |author = Dong, Y.H., Wang, L.H., Xu, J.L., Zhang, H.B., Zhang, X.F. and Zhang, L.H. |journal = Nature |date = 2001 |volume = 411 |pages = 813-817 |pmid = 11459062}}</ref><ref>{{cite journal | title = Genes encoding the ''N''-acyl homoserine lactone-degrading enzyme are widespread in many subspecies of ''Bacillus thuringiensis'' | url = https://archive.org/details/sim_applied-and-environmental-microbiology_2002-08_68_8/page/3919 |author = Lee, S.J., Park, S.Y., Lee, J.J., Yum, D.Y., Koo, B.T. and Lee, J.K. |journal = Appl. Environ. Microbiol. |date = 2002 |volume = 68 |pages = 3919-3924 |pmid = 12147491}}</ref><ref>{{cite journal | title = AhlD, an ''N''-acylhomoserine lactonase in ''Arthrobacter sp''., and predicted homologues in other bacteria |author = Park, S.Y., Lee, S.J., Oh, T.K., Oh, J.W., Koo, B.T., Yum, D.Y. and Lee, J.K. |journal = Microbiology |date = 2003 |volume = 149 |pages = 1541-1550 |pmid = 12777494}}</ref><ref>{{cite journal | title = Quorum quenching: enzymatic disruption of ''N''-acylhomoserine lactone-mediated bacterial communication in ''Burkholderia thailandensis'' | url = https://archive.org/details/sim_applied-and-environmental-microbiology_2004-10_70_10/page/6173 |author = Ulrich, R.L. |journal = Appl. Environ. Microbiol. |date = 2004 |volume = 70 |pages = 6173-6180 |pmid = 15466564}}</ref><ref>{{cite journal | title = The molecular structure and catalytic mechanism of a quorum-quenching ''N''-acyl-<small>L</small>-homoserine lactone hydrolase |author = Kim, M.H., Choi, W.C., Kang, H.O., Lee, J.S., Kang, B.S., Kim, K.J., Derewenda, Z.S., Oh, T.K., Lee, C.H. and Lee, J.K. |journal = Proc. Natl. Acad. Sci. USA |date = 2005 |volume = 102 |pages = 17606-17611 |pmid = 16314577}}</ref><ref>{{cite journal | title = Three-dimensional structure of the quorum-quenching ''N''-acyl homoserine lactone hydrolase from ''Bacillus thuringiensis'' |author = Liu, D., Lepore, B.W., Petsko, G.A., Thomas, P.W., Stone, E.M., Fast, W. and Ringe, D. |journal = Proc. Natl. Acad. Sci. USA |date = 2005 |volume = 102 |pages = 11882-11887 |pmid = 16087890}}</ref><ref>{{cite journal | title = Quorum quenching enzyme activity is widely conserved in the sera of mammalian species |author = Yang, F., Wang, L.H., Wang, J., Dong, Y.H., Hu, J.Y. and Zhang, L.H. |journal = FEBS Lett. |date = 2005 |volume = 579 |pages = 3713-3717 |pmid = 15963993}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: -{N}--acil--{L}--homoserin lakton + -{H}-<sub>2</sub>O <math>\rightleftharpoons</math> -{N}--acil--{L}--homoserin

[[Acil-homoserinski lakton|Acil-homoserinske laktone]] (AHL) formiraju [[gram negativne bakterije]] i obično ih koriste kao [[signalni molekul]] za međusobnu komunikaciju u procesu [[kvorum-sensing]]a. AHL se vezuje za [[transkripcioni faktor|transkripcione faktore]] i na taj način utiče na [[ekspresija gena|ekspresiju gena]]. Ovim vidom komunikacije bakterije regulišu brojne biološke funkcije, uključujući i [[sekrecija|sekreciju]] faktora [[virulencija|virulencije]].

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{JencksCatalysisInChemistryAndEnzymology}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|Quorum-quenching+N-acyl-homoserine+lactonase}}

{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

{{normativna kontrola}}

[[Категорија:ЕЦ 3.1.1]]