Изворни код странице Ksantin oksidaza

{{Infobox Enzim-lat
| Name = Ksantin oksidaza
| EC_number = 1.17.3.2
| CAS_number = 9002-17-9
| IUBMB_EC_number = 1/17/3/2
| GO_code = 
| image = XanthineOxidase-1FIQ.png
| width = 
| caption =
}}
'''Ksantin oksidaza''' ({{EC broj-lat|1.17.3.2}}, ''hipoksantinska oksidaza'', ''hipoksantin:kiseonik oksidoreduktaza'', ''-{Schardinger}- enzim'', ''ksantinska oksidoreduktaza'', ''hipoksantin-ksantinska oksidaza'', ''ksantin:O<sub>2</sub> oksidoreduktaza'', ''ksantin:ksantine oksidaza'') je [[enzim]] sa sistematskim imenom ''ksantin:kiseonik oksidoreduktaza''.<ref>{{cite journal | title = Cellular constituents. The chemistry of xanthine oxidase. Part I. The preparation of a crystalline xanthine oxidase from cow's milk |author = Avis, P.G., Bergel, F. and Bray, R.C. |journal = J. Chem. Soc. (Lond.) |date = 1955 |volume =  |pages = 1100-1105 |pmid = }}</ref><ref>{{cite journal | title = Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver |author1=Battelli, M.G.  |author2=Lorenzoni, E.  |lastauthoramp=yes |journal = Biochem. J. |date = 1982 |volume = 207 |pages = 133-138 |pmid = 6960894}}</ref><ref>{{Cite book | chapter = Xanthine oxidase | title = The Enzymes |author = Bray, R.C. |date = 1963 |volume = 7 |pages = 533-556 |editor1=Boyer, P.D., Lardy, H. |editor2=Myrb |editor3=auml |editor4=ck, K. |edition  = 2nd |publisher = Academic Press |location = New York }}</ref><ref>{{cite journal | title = The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme | url = https://archive.org/details/sim_biochemical-journal_1972-02_126_3/page/739 |author1=Della Corte, E.  |author2=Stirpe, F.  |lastauthoramp=yes |journal = Biochem. J. |date = 1972 |volume = 126 |pages = 739-745 |pmid = 4342395}}</ref><ref>{{cite journal | title = The presence of desulfo xanthine dehydrogenase in purified and crude enzyme preparations from rat liver |author1=Ikegami, T.  |author2=Nishino, T.  |lastauthoramp=yes |journal = Arch. Biochem. Biophys. |date = 1986 |volume = 247 |pages = 254-260 |pmid = 3459393}}</ref><ref>{{cite journal | title = Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues | url = https://archive.org/details/sim_journal-of-clinical-investigation_1987-06_79_6/page/1564 |author = Engerson, T.D., McKelvey, T.G., Rhyne, D.B., Boggio, E.B., Snyder, S.J. and Jones, H.P. |journal = J. Clin. Invest. |date = 1987 |volume = 79 |pages = 1564-1570 |pmid = 3294898}}</ref><ref>{{cite journal | title = Interconversion between NAD-dependent and O<small><sub>2</sub></small>-dependent types of rat liver xanthine dehydrogenase and difference in kinetic and redox properties between them |author = Saito, T., Nishino, T. and Tsushima, K. |journal = Adv. Exp. Med. Biol. |date = 1989 |volume = 253B |pages = 179-183 |pmid = 2610112}}</ref><ref>{{cite journal | title = Purification and characterization of mouse liver xanthine oxidase |author = Carpani, G., Racchi, M., Ghezzi, P., Terao, M. and Garattini, E. |journal = Arch. Biochem. Biophys. |date = 1990 |volume = 279 |pages = 237-241 |pmid = 2350174}}</ref><ref>{{cite journal | title = Purification, crystallization and preliminary X-ray diffraction studies of xanthine dehydrogenase and xanthine oxidase isolated from bovine milk |author = Eger, B.T., Okamoto, K., Enroth, C., Sato, M., Nishino, T., Pai, E.F. and Nishino, T. |journal = Acta Crystallogr. D Biol. Crystallogr. |date = 2000 |volume = 56 |pages = 1656-1658 |pmid = 11092937}}</ref><ref>{{cite journal | title = Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase |author = Nishino, T., Okamoto, K., Eger, B.T., Pai, E.F. and Nishino, T. |journal = FEBS J. |date = 2008 |volume = 275 |pages = 3278-3289 |pmid = 18513323}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: [[ksantin]] + -{H}-<sub>2</sub>O + O<sub>2</sub> <math>\rightleftharpoons</math> [[urat]] + -{H}-<sub>2</sub>O<sub>2</sub>

Ovaj [[gvožđe]]-[[molibden]]ski flavoprotein (FAD) sadrži [2-{Fe-2S}-] centre. On takođe oksiduje [[hipoksantin]], neke druge [[purin]]e i [[pterin]]e, i [[aldehid]]e.

== Reference ==
{{reflist}}

== Литература ==
* {{Cite book |ref= harv|chapter = Xanthine oxidase | title = The Enzymes |author = Bray, R.C. |date = 1963 |volume = 7 |pages = 533-556 |editor1=Boyer, P.D., Lardy, H. |editor2=Myrb |editor3=auml |editor4=ck, K. |edition  = 2nd |publisher = Academic Press |location = New York }}

== Spoljašnje veze ==
* {{MeshName|Xanthine+oxidase}}

{{Alkoholne oksidoreduktaze-lat}}
{{Druge oksidoreduktaze-lat}}
{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

{{normativna kontrola}}

[[Категорија:ЕЦ 1.17.3]]