Изворни код странице Glicerol-1-fosfat dehidrogenaza (NAD(P)+)

{{Infobox Enzim-lat
| Name = Glicerol-1-fosfat dehidrogenaza (-{NAD(P)}-<sup>+</sup>)
| EC_number = 1.1.1.261
| CAS_number = 204594-18-3
| IUBMB_EC_number = 1/1/1/261
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Glicerol-1-fosfat dehidrogenaza (-{NAD(P)}-<sup>+</sup>)''' ({{EC broj-lat|1.1.1.261}}, ''-{sn}--glicerol-1-fosfat:-{NAD}-<sup>+</sup> oksidoreduktaza'', ''-{G-1-P}- dehidrogenaza'', -{''Gro1PDH'', ''AraM''}-) je [[enzim]] sa sistematskim imenom ''-{sn}--glicerol-1-fosfat:-{NAD(P)}-<sup>+</sup> 2-oksidoreduktaza''.<ref>{{cite journal | title = ''sn''-Glycerol-1-phosphate dehydrogenase in ''Methanobacterium thermoautotrophicum'': key enzyme in biosynthesis of the enantiomeric  glycerophosphate backbone of ether phospholipids of archaebacteria |author1=Nishihara, M.  |author2=Koga, Y.  |lastauthoramp=yes |journal = J. Biochem. |date = 1995 |volume = 117 |pages = 933-935 |pmid = 8586635}}</ref><ref>{{cite journal | title = Purification and properties of ''sn''-glycerol-1-phosphate dehydrogenase from ''Methanobacterium thermoautotrophicum'': characterization of the biosynthetic  enzyme for the enantiomeric glycerophosphate backbone of ether polar  lipids of ''Archaea'' |author1=Nishihara, M.  |author2=Koga, Y.  |lastauthoramp=yes |journal = J. Biochem. |date = 1997 |volume = 122 |pages = 572-576 |pmid = 9348086}}</ref><ref>{{cite journal | title = Did archaeal and bacterial cells arise independently from noncellular precursors? A hypothesis stating that the advent of membrane phospholipid with enantiomeric glycerophosphate backbones caused the separation of the two lines of descent | url = https://archive.org/details/sim_journal-of-molecular-evolution_1998-01_46_1/page/54 |author = Koga, Y., Kyuragi, T., Nishihara, M. and Sone, N. |journal = J. Mol. Evol. |date = 1998 |volume = 46 |pages = 54-63 |pmid = 9419225}}</ref><ref>{{cite journal | title = CTP:2,3-di-''O''-geranylgeranyl-''sn''-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon ''Methanothermobacter thermoautotrophicus'' |author = Morii, H., Nishihara, M. and Koga, Y. |journal = J. Biol. Chem. |date = 2000 |volume = 275 |pages = 36568-36574 |pmid = 10960477}}</ref><ref>{{cite journal | title = Active site of Zn<small><sup>2+</sup></small>-dependent ''sn''-glycerol-1-phosphate dehydrogenase from ''Aeropyrum pernix'' K1 |author1=Han, J.S.  |author2=Ishikawa, K.  |lastauthoramp=yes |journal = Archaea |date = 2005 |volume = 1 |pages = 311-317 |pmid = 15876564}}</ref><ref>{{cite journal | title = Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from ''Bacillus subtilis'' |author = Guldan, H., Sterner, R. and Babinger, P. |journal = Biochemistry |date = 2008 |volume = 47 |pages = 7376-7384 |pmid = 18558723}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: -{sn}--glicerol-1-fosfat + -{NAD(P)}-+ <math>\rightleftharpoons</math> gliceron fosfat + -{NAD(P)H + H}-<sup>+</sup>

Ovaj enzim se prvenstveno nalazi u -{Zn}-<sup>2+</sup>-zavisnoj formi kod [[arheja]], dok je -{Ni}-<sup>2+</sup>-zavisna forma prisutna kod Gram-pozitivnih bakterija. -{Zn}-<sup>2+</sup>-zavisni metaloenzim je odgovoran za formiranje arhejski-specifičnog -{sn}--glicerol-1-fosfata, u prvom koraku biosinteze polarnih lipida. On je [[enantiomer]] -{sn}--glicerol 3-fosfata, forme  glicerofosfata prisutnog kod [[bakterija]] i [[eukariote|eukariota]]. Drugi enzimi koji učestvuju u biosintezi polarnih lipida kod arheja su [[EC 2.5.1.41]], fosfoglicerol geranilgeraniltransferaza, i [[EC 2.5.1.42]], (geranilgeranilglicerol-fosfat geranilgeraniltransferaza, koji zajedno alkiliraju hidroksi grupe glicerol 1-fosfata i proizvode nezasićenu arhetidinsku kiselinu, na koju deluje [[EC 2.7.7.67]], -{CDP}--arheolna sintaza, da formira -{CDP}--nezasićeni arheol. Krajnji korak ovog sintetičkog puta je adicija -{L}--serina, sa pratećim uklanjanjem -{CMP}--a, što dovodi do produkcije nezasićenog arhetidilserina. Aktivnost ovog enzima stimuliše -{K}-<sup>+</sup>.

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{JencksCatalysisInChemistryAndEnzymology}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|glycerol-1-phosphate+dehydrogenase}}

{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

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[[Категорија:ЕЦ 1.1.1]]