Изворни код странице Dolihil-P-Man:Man7GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza

{{Infobox Enzim-lat
| Name = Dolihil--{P-Man:Man7GlcNAc2-PP}--dolihol alfa-1,6-manoziltransferaza
| EC_number = 2.4.1.260
| CAS_number = 
| IUBMB_EC_number = 2/4/1/260
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Dolihil--{P-Man:Man7GlcNAc2-PP}--dolihol alfa-1,6-manoziltransferaza''' ({{EC broj-lat|2.4.1.260}}, -{''ALG12'', ''ALG12}- manoziltransferaza'', ''-{ALG12}- alfa1,6manoziltransferaza'', ''dolihil--{P}--manoza:-{Man7GlcNAc2-PP}--dolihil manoziltransferaza'', ''dolihil--{P-Man:Man7GlcNAc2-PP-dolihil alfa6}--manoziltransferaza'', -{''EBS4'', ''Dol-P-Man:Man7GlcNAc2-PP-Dol alfa}--1,6-manoziltransferaza'') je [[enzim]] sa sistematskim imenom ''dolihil beta-D-manozil fosfat:-{D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-(D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-D-Man-alfa-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc}--difosfodolihol alfa-1,6-manoziltransferaza''.<ref>{{cite journal | title = ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis |author1=Frank, C.G.  |author2=Aebi, M.  |lastauthoramp=yes |journal = Glycobiology |date = 2005 |volume = 15 |pages = 1156-1163 |pmid = 15987956}}</ref><ref>{{cite journal | title = Mutations of an &alpha;1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in  ''Arabidopsis'' |author = Hong, Z., Jin, H., Fitchette, A.C., Xia, Y., Monk, A.M., Faye, L. and Li, J. |journal = Plant Cell |date = 2009 |volume = 21 |pages = 3792-3802 |pmid = 20023196}}</ref><ref>{{cite journal | title = The ''Saccharomyces cerevisiae'' alg12&delta; mutant reveals a role for the middle-arm &alpha;1,2Man- and upper-arm &alpha;1,2Man&alpha;1,6Man- residues of  Glc<sub>3</sub>Man<sub>9</sub>GlcNAc<sub>2</sub>-''PP''-Dol in regulating glycoprotein glycan processing in the  endoplasmic reticulum and Golgi apparatus |author1=Cipollo, J.F.  |author2=Trimble, R.B.  |lastauthoramp=yes |journal = Glycobiology |date = 2002 |volume = 12 |pages = 749-762 |pmid = 12460943}}</ref><ref>{{cite journal | title = ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg |author = Grubenmann, C.E., Frank, C.G., Kjaergaard, S., Berger, E.G., Aebi, M. and Hennet, T. |journal = Hum. Mol. Genet. |date = 2002 |volume = 11 |pages = 2331-2339 |pmid = 12217961}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: dolihil beta--{D}--manozil fosfat + -{D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc}--difosfodolihol <math>\rightleftharpoons</math> -{D-Man-alfa-(1->2)-D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->2)-D-Man-alfa-(1->3)-[D-Man-alfa-(1->6)]-D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc}--difosfodolihol + [[dolihil fosfat]]

Tokom formiranja -{N}--glikozilnih veza glikoproteina dolazi do uređivanja sklopa rasprostanjenih [[oligosaharida]] sa -{Glc3Man9GlcNAc2}- osnovom na lipidnom nosiocu dolihil difosfatu.

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|Dolichyl-P-Man:Man7GlcNAc2-PP-dolichol+alpha-1,6-mannosyltransferase}}

{{Glikoziltransferaze-lat}}
{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

{{normativna kontrola}}

[[Категорија:ЕЦ 2.4.1]]