Изворни код странице Arahidonat 5-lipoksigenaza

{{Infobox Enzim-lat
| Name = Arachidonat 5-lipoksigenaza
| EC_number = 1.13.11.34
| CAS_number = 80619-02-9
| IUBMB_EC_number = 1/13/11/34
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Arahidonat 5-lipoksigenaza''' ({{EC broj-lat|1.13.11.34}}, ''leukotrien-A4 sintaza'', ''Delta5-lipoksigenaza'', ''5Delta-lipoksigenaza'', ''arahidonska 5-lipoksigenaza'', ''arahidonska kiselina 5-lipoksigenaza'', ''-{C}--5-lipoksigenaza'', ''LTA sintaza'', ''leukotrienska A4 sintaza'') je [[enzim]] sa sistematskim imenom ''arachidonat:kiseonik 5-oksidoreduktaza''.<ref>{{cite journal | title = Molecular cloning and amino acid sequence of human 5-lipoxygenase |author = Matsumoto, T., Funk, C.D., Radmark, O., Hoog, J.-O., Jornvall, H. and Samuelsson, B. |journal = Proc. Natl. Acad. Sci. USA |date = 1988 |volume = 85 |pages = 26-30 |pmid = 2829172}}</ref><ref>{{cite journal | title = Leukotriene A<small><sub>4</sub></small> hydrolase in the human lung. Inactivation of the enzyme with leukotriene A<small><sub>4</sub></small> isomers |author = Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. |journal = J. Biol. Chem. |date = 1987 |volume = 262 |pages = 10200-10205 |pmid = 3038871}}</ref><ref>{{cite journal | title = Characterization of leukotriene A<small><sub>4</sub></small> synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase |author = Shimizu, T., Izumi, T., Seyama, Y., Tadokoro, K., R&auml;dmark, O. and Samuelsson, B. |journal = Proc. Natl. Acad. Sci. USA |date = 1986 |volume = 83 |pages = 4175-4179 |pmid = 3012557}}</ref><ref>{{cite journal | title = Enzyme with dual lipoxygenase activities catalyzes leukotriene A<small><sub>4</sub></small> synthesis from arachidonic acid |author = Shimizu, T., R&auml;dmark, O. and Samuelssohn, B. |journal = Proc. Natl. Acad. Sci. USA |date = 1984 |volume = 81 |pages = 689-693 |pmid = 6322165}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: arahidonat + O<sub>2</sub> <math>\rightleftharpoons</math> leukotrien A4 + -{H}-<sub>2</sub>O (sveukupna reakcija)
:(1a) arahidonat + O<sub>2</sub> <math>\rightleftharpoons</math> -{(6E,8Z,11Z,14Z)-(5S)}--5-hidroperoksiikosa-6,8,11,14-tetraenoat
:(1b) -{(6E,8Z,11Z,14Z)-(5S)}--5-hidroperoksiikosa-6,8,11,14-tetraenoat <math>\rightleftharpoons</math> leukotrien A4 +-{H}-<sub>2</sub>O

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|Arachidonate+5-lipoxygenase}}

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{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

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[[Категорија:ЕЦ 1.13.11]]