Изворни код странице ATP citratna lijaza

{{protein-lat
|Name=ATP citratna lijaza
|caption=Kristalna struktura skraćene ljudske ATP-citratne lijaze.<ref name="pmid20558738">{{PDB|3MWE}}; {{cite journal |vauthors=Sun T, Hayakawa K, Bateman KS, Fraser ME | title = Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography | journal = J. Biol. Chem. | volume = 285 | issue = 35 | pages = 27418–27428 | year = 2010 | pmid = 20558738 | doi = 10.1074/jbc.M109.078667 | url = | issn = | pmc = 2930740 }}</ref>
|image= Atpcitratelyase.pdb.png
|width=
|HGNCid=115
|Symbol=ACLY
|AltSymbols=
|EntrezGene=47
|OMIM=108728
|RefSeq=NM_001096
|UniProt=P53396
|PDB=
|ECnumber=2.3.3.8  
|Chromosome=17
|Arm=q
|Band=21.2
|LocusSupplementaryData=
}}
'''ATP citratna lijaza''' je [[enzim]] koji posreduje jedan važan korak u [[Sinteza masnih kiselina|biosintezi masnih kiselina]].<ref name="pmid1371749">{{cite journal | vauthors = Elshourbagy NA, Near JC, Kmetz PJ, Wells TN, Groot PH, Saxty BA, Hughes SA, Franklin M, Gloger IS | title = Cloning and expression of a human ATP-citrate lyase cDNA | journal = Eur. J. Biochem. | volume = 204 | issue = 2 | pages = 491–499 | year = 1992 | pmid = 1371749 | doi = 10.1111/j.1432-1033.1992.tb16659.x}}</ref> ATP citratna lijaza je veza između metabolizma ugljenih hidrata (kojim se oslobađa energija) i produkcije masnih kiselina.<ref name = "pmid20558738"/>

==Funkcija==
ATP citratna lijaza je primarni enzim odgovoran za sintezu [[citosol]]nog [[acetil-KoA]] u mnogim tkivima. Ovaj enzim je tetramer identičnih podjedinica. Produkat, acetil-KoA, se koristi u nekoliko biosintetičkih puteva, uključujući [[lipogeneza|lipogenezu]] i [[Mevalonatni put|holesterogenezu]].<ref name="entrez">{{cite web | title = Entrez Gene: ATP citrate lyase | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=47 | accessdate = }}</ref> Aktivira ga [[insulin]].<ref name="pmid17928289">{{cite journal |vauthors=Guay C, Madiraju SR, Aumais A, Joly E, Prentki M | title = A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion | journal = J. Biol. Chem. | volume = 282 | issue = 49 | pages = 35657–35665 | year = 2007 | pmid = 17928289 | doi = 10.1074/jbc.M707294200 | url =  }}</ref> ATP-citratna lijaza je takođe odgovorna za katalizu konverzije [[citrat]]a i [[koenzim A|KoA]] u [[acetil-KoA]] i [[Oksalosirćetna kiselina|oksaloacetat]], uz ATP hidrolizu.<ref name = "pmid20558738"/>

==Reakcija==
U prisustvu [[Adenozin trifosfat|ATP-a]] i [[Koenzim A|koenzima A]], citratna lijaza katalizuje odvajanje [[citrat]]a čime nastaju [[Acetil koenzim A|acetil KoA]], [[oksaloacetat]], [[Adenozin difosfat|ADP]], i [[ortofosfat]]:

:citrat + ATP + KoA + -{H<sub>2</sub>O}- <math>\rightleftharpoons</math> oksaloacetat + [[Acetil-KoA]] + ADP + -{Pi}-.

Ovaj enzim je ranije bio klasifikovan kao EC 4.1.3.8.<ref>{{MeshName|ATP+Citrate+Lyase}}</ref>

==Lokacija==
Ovaj enzim se nalazi u [[citosol]]u biljki<ref name="pmid12376641">{{cite journal |vauthors=Fatland BL, Ke J, Anderson MD, Mentzen WI, Cui LW, Allred CC, Johnston JL, Nikolau BJ, Wurtele ES | title = Molecular characterization of a heteromeric ATP-citrate lyase that generates cytosolic acetyl-coenzyme A in Arabidopsis | journal = Plant Physiol. | volume = 130 | issue = 2 | pages = 740–756 | year = 2002 | pmid = 12376641 | pmc = 166603 | doi = 10.1104/pp.008110 | url =https://archive.org/details/sim_plant-physiology_2002-10_130_2/page/740}}</ref> i životinja.

== Reference ==
{{Reflist|2}}

== Literatura ==
{{Литература}}
* {{cite journal |vauthors=Lovell SC, Davis IW, Arendall WB, de Bakker PI, Word JM, Prisant MG, Richardson JS, Richardson DC | title = Structure validation by Calpha geometry: phi,psi and Cbeta deviation | journal = Proteins | volume = 50 | issue = 3 | pages = 437–450 | year = 2003 | pmid = 12557186 | doi = 10.1002/prot.10286 | url = | issn = }}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|ATP+Citrate+Lyase|3=ATP Citrate Lyase}}
* [https://web.archive.org/web/20121019183028/http://www.rcsb.org/pdb/images/3MWD_ram_m_500.pdf -{Ramachandran Plot of ATP Citrate Lyase}-]

{{Aciltransferaze-lat}}

[[Категорија:ЕЦ 2.3.3]]
[[Категорија:Циклус лимунске киселине]]