Изворни код странице 3-Oksoacil-(acil-nosilac-protein) sintaza

{{Infobox Enzim-lat
| Name = 3-Oksoacil-(acil-nosilac-protein) sintaza
| EC_number = 2.3.1.41
| CAS_number = 2621625
| IUBMB_EC_number = 2/3/1/41
| GO_code = 
| image = 
| width = 
| caption =
}}
'''3-Oksoacil-(acil-nosilac-protein) sintaza''' ({{EC broj-lat|2.3.1.41}}, ''beta-ketoacil-ACP sintaza I'', ''beta-ketoacilna sintetaza'', ''beta-ketoacil-ACP sintetaza'', ''beta-ketoacil-acil nosilac protein sintetaza'', ''beta-ketoacil-(acil nosilac protein) sintaza'', ''beta-ketoacilsintaza'', ''3-ketoacil-acil nosilac protein sintaza'', ''beta-ketoacil acil nosilac protein sintaza'', ''3-oksoacil:ACP sintaza I'', -{''KASI'', ''KAS I'', ''FabF1'', ''FabB''}-, ''acil-(acil-nosilac-protein):malonil-(acil-nosilac-protein) C-aciltransferaza (dekarboksilacija)'') je [[enzim]] sa sistematskim imenom ''acil-(acil-nosilac protein):malonil-(acil-nosilac protein) C-aciltransferaza (dekarboksilacija)''.<ref>{{cite journal | title = Acetyl-CoA acyl carrier protein transacylase |author = Alberts, A.W., Majerus, P.W. and Vagelos, P.R. |journal = Methods Enzymol. |date = 1969 |volume = 14 |pages = 50-53 |pmid = }}</ref><ref>{{cite journal | title = Acyl carrier protein |author1=Prescott, D.J.  |author2=Vagelos, P.R.  |lastauthoramp=yes |journal = Adv. Enzymol. Relat. Areas Mol. Biol. |date = 1972 |volume = 36 |pages = 269-311 |pmid = 4561013}}</ref><ref>{{cite journal | title = Studies on the mechanism of fatty acid synthesis. XVI. Preparation and general properties of acyl-malonyl acyl carrier protein-condensing enzyme from ''Escherichia coli'' |author1=Toomey, R.E.  |author2=Wakil, S.J.  |lastauthoramp=yes |journal = J. Biol. Chem. |date = 1966 |volume = 241 |pages = 1159-1165 |pmid = 5327099}}</ref><ref>{{cite journal | title = Multiple forms of β-ketoacyl-acyl carrier protein synthetase in ''Escherichia coli'' |author = D'Agnolo, G., Rosenfeld, I.S. and Vagelos, P.R. |journal = J. Biol. Chem. |date = 1975 |volume = 250 |pages = 5289-5294 |pmid = 237914}}</ref><ref>{{cite journal | title = Structural, enzymatic, and genetic studies of β-ketoacyl-acyl carrier protein synthases I and II of ''Escherichia coli'' |author = Garwin, J.L., Klages, A.L. and Cronan, J.E., Jr.. |journal = J. Biol. Chem. |date = 1980 |volume = 255 |pages = 11949-11956 |pmid = 7002930}}</ref><ref>{{cite journal | title = Functional replacement of the FabA and FabB proteins of ''Escherichia coli'' fatty acid synthesis by ''Enterococcus faecalis'' FabZ and FabF homologues |author1=Wang, H.  |author2=Cronan, J.E.  |lastauthoramp=yes |journal = J. Biol. Chem. |date = 2004 |volume = 279 |pages = 34489-34495 |pmid = 15194690}}</ref><ref>{{Cite book | chapter = Biosynthesis of membrane lipids | title = Escherichia coli and Salmonella: Cellular and Molecular Biology |author1=Cronan, J.E., Jr.  |author2=Rock, C.O.  |lastauthoramp=yes |date = 1996 |volume = 1 |pages = 612-636 |editor = Neidhardt, F.C. |edition  = 2nd |publisher = ASM Press |location = Washington, DC }}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: acil-[acil-nosilac protein] + malonil-[acil-nosilac protein] <math>\rightleftharpoons</math> 3-oksoacil-[acil-nosilac protein] + -{CO}-<sub>2</sub> + [acil-nosilac protein]

Ovaj enzim je odgovoran za produžavanje lanca pri biosintezi disociranih (tip II) [[masna kiselina|masnih kiselina]], i.e. adicija dva -{C}- atoma na masno kiselinski lanac. -{''[[Escherichia coli]]''}- mutanti kojima nedostaje ovaj enzim su deficitarni u nezasićenim masnim kiselinama.

== Reference ==
{{reflist}}

== Литература ==
* {{Cite book |ref= harv|chapter = Biosynthesis of membrane lipids | title = Escherichia coli and Salmonella: Cellular and Molecular Biology |author1=Cronan, J.E., Jr.  |author2=Rock, C.O.  |lastauthoramp=yes |date = 1996 |volume = 1 |pages = 612-636 |editor = Neidhardt, F.C. |edition  = 2nd |publisher = ASM Press |location = Washington, DC }}

== Spoljašnje veze ==
* {{MeshName|Beta-ketoacyl-(acyl-carrier-protein)+synthase+I}}

{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

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[[Категорија:ЕЦ 2.3.1]]