Изворни код странице 16S rRNK (adenin1518-N6/adenin1519-N6)-dimetiltransferaza

{{Infobox Enzim-lat
| Name = 16-{S}- rRNK (adenin<sup>1518</sup>--{N}-<sup>6</sup>/adenin<sup>1519</sup>--{N}-<sup>6</sup>)-dimetiltransferaza
| EC_number = 2.1.1.182
| CAS_number = 
| IUBMB_EC_number = 2/1/1/182
| GO_code = 
| image = 
| width = 
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}}
'''16-{S}- rRNK (adenin<sup>1518</sup>--{N}-<sup>6</sup>/adenin<sup>1519</sup>--{N}-<sup>6</sup>)-dimetiltransferaza''' ({{EC broj-lat|2.1.1.182}}, ''-{S}--adenozilmetionin-6--{N',N'}--adenozil (rRNK) dimetiltransferaza'', -{''KsgA'', ''ksgA}- metiltransferaza'') je [[enzim]] sa sistematskim imenom ''-{S}--adenozil--{L}--metionin:16-{S}- rRNK (adenin<sup>1518</sup>--{N}-<sup>6</sup>/adenin<sup>1519</sup>--{N}-<sup>6</sup>)-dimetiltransferaza''.<ref>{{cite journal | title = Change in methylation of 16S ribosomal RNA associated with mutation to kasugamycin resistance in ''Escherichia coli'' | url = https://archive.org/details/sim_nature-uk_1971-09-10_233_5315/page/n95 |author = Helser, T.L., Davies, J.E. and Dahlberg, J.E. |journal = Nat. New Biol. |date = 1971 |volume = 233 |pages = 12-14 |pmid = 4329247}}</ref><ref>{{cite journal | title = Mechanism of kasugamycin resistance in ''Escherichia coli'' |author = Helser, T.L., Davies, J.E. and Dahlberg, J.E. |journal = Nat. New Biol. |date = 1972 |volume = 235 |pages = 6-9 |pmid = 4336392}}</ref><ref>{{cite journal | title = Nucleotide sequence of the ''ksgA'' gene of ''Escherichia coli'': comparison of methyltransferases effecting dimethylation of adenosine in ribosomal RNA |author1=van Buul, C.P.  |author2=van Knippenberg, P.H.  |lastauthoramp=yes |journal = Gene |date = 1985 |volume = 38 |pages = 65-72 |pmid = 3905517}}</ref><ref>{{cite journal | title = Methylation of the conserved A<small><sup>1518</sup></small>-A<small><sup>1519</sup></small> in ''Escherichia coli'' 16S ribosomal RNA by the ''ksgA'' methyltransferase is influenced by methylations around the  similarly conserved U<small><sup>1512</sup></small>.G<small><sup>1523</sup></small> base pair in the 3′ terminal hairpin | url = https://archive.org/details/sim_biochimie_1994_76_12/page/1123 |author = Formenoy, L.J., Cunningham, P.R., Nurse, K., Pleij, C.W. and Ofengand, J. |journal = Biochimie |date = 1994 |volume = 76 |pages = 1123-1128 |pmid = 7538324}}</ref><ref>{{cite journal | title = Crystal structure of KsgA, a universally conserved rRNA adenine dimethyltransferase in ''Escherichia coli'' |author = O'Farrell, H.C., Scarsdale, J.N. and Rife, J.P. |journal = J. Mol. Biol. |date = 2004 |volume = 339 |pages = 337-353 |pmid = 15136037}}</ref><ref>{{cite journal | title = Studies on the function of two adjacent ''N''<small><sup>6</sup></small>,''N''<small><sup>6</sup></small>-dimethyladenosines near the 3′ end of 16 S ribosomal RNA of ''Escherichia coli''. III. Purification and  properties of the methylating enzyme and methylase-30 S interactions |author = Poldermans, B., Roza, L. and Van Knippenberg, P.H. |journal = J. Biol. Chem. |date = 1979 |volume = 254 |pages = 9094-9100 |pmid = 383712}}</ref><ref>{{cite journal | title = Structural rearrangements in the active site of the ''Thermus thermophilus'' 16S rRNA methyltransferase KsgA in a binary complex with 5′-methylthioadenosine |author = Demirci, H., Belardinelli, R., Seri, E., Gregory, S.T., Gualerzi, C., Dahlberg, A.E. and Jogl, G. |journal = J. Mol. Biol. |date = 2009 |volume = 388 |pages = 271-282 |pmid = 19285505}}</ref><ref>{{cite journal | title = Structural basis for binding of RNA and cofactor by a KsgA methyltransferase |author = Tu, C., Tropea, J.E., Austin, B.P., Court, D.L., Waugh, D.S. and Ji, X. |journal = Structure |date = 2009 |volume = 17 |pages = 374-385 |pmid = 19278652}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: 4 -{S}--adenozil--{L}--metionin + [[adenin]]<sup>1518</sup>/adenin<sup>1519</sup> u 16-{S}- rRNK <math>\rightleftharpoons</math> 4 -{S}--adenozil--{L}--[[homocistein]] + -{N}-<sup>6</sup>-dimetiladenin<sup>1518</sup>/-{N}-<sup>6</sup>-dimetiladenin<sup>1519</sup> u 16-{S}- rRNK

-{KsgA}- proizvodi modifikaciju ribozomalne RNK koja je u najvećoj meri konzervirana, dimetilaciju [[adenin]]a<sup>1518</sup> i adenina<sup>1519</sup> u 16-{S}- rRNK. Vrste koje nemaju ovu metilazu su otporne na [[kasugamicin]].

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|16S+rRNA+(adenine1518-N6/adenine1519-N6)-dimethyltransferase}}

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[[Категорија:ЕЦ 2.1.1]]