Изворни код странице 1-pirolin-5-karboksilat dehidrogenaza

{{Infobox Enzim-lat
| Name = 1-pirolin-5-karboksilat dehidrogenaza
| EC_number = 1.5.1.12
| CAS_number = 9054-82-4
| IUBMB_EC_number = 1/5/1/12
| GO_code = 
| image = 
| width = 
| caption =
}}
'''1-pirolin-5-karboksilat dehidrogenaza''' ({{EC broj-lat|1.5.1.12}}, ''Delta1-pirolidin-5-karboksilat dehidrogenaza'', ''1-pirolidinska dehidrogenaza'', ''pirolidin-5-karboksilatna dehidrogenaza'', ''pirolidin-5-karboksilna kiselina dehidrogenaza'', ''-{L}--pirolidin-5-karboksilat--{NAD}-<sup>+</sup> oksidoreduktaza'', ''1-pirolidin-5-karboksilat:-{NAD}-<sup>+</sup> oksidoreduktaza'', ''Delta1-pirolidin-5-karboksilna kiselina dehidrogenaza'') je [[enzim]] sa sistematskim imenom ''(-{S}-)-1-pirolidin-5-karboksilat:-{NAD}-<sup>+</sup> oksidoreduktaza''.<ref>{{cite journal | title = Hydroxyproline metabolism. IV. Enzymatic synthesis of γ-hydroxyglutamate from Δ<sup>1</sup>-pyrroline-3-hydroxy-5-carboxylate | url = https://archive.org/details/sim_journal-of-biological-chemistry_1960-12_235_12/page/3504 |author1=Adams, E.  |author2=Goldstone, A.  |lastauthoramp=yes |journal = J. Biol. Chem. |date = 1960 |volume = 235 |pages = 3504-3512 |pmid = 13681370}}</ref><ref>{{cite journal | title = The interconversion of glutamic acid and proline. III. Δ<sup>1</sup>-Pyrroline-5-carboxylic acid dehydrogenase | url = https://archive.org/details/sim_journal-of-biological-chemistry_1960-11_235_11/page/3218 |author = Strecker, H.J. |journal = J. Biol. Chem. |date = 1960 |volume = 235 |pages = 3218-3223 |pmid = }}</ref><ref>{{cite journal | title = Δ<sup>1</sup>-Pyrroline-5-carboxylate dehydrogenase from cultured cells of potato (purification and properties) | url = https://archive.org/details/sim_plant-physiology_1997-04_113_4/page/1413 |author = Forlani, G., Scainelli, D. and Nielsen, E. |journal = Plant Physiol. |date = 1997 |volume = 113 |pages = 1413-1418 |pmid = 12223682}}</ref><ref>{{cite journal | title = Redesigned purification yields a fully functional PutA protein dimer from ''Escherichia coli'' |author1=Brown, E.D.  |author2=Wood, J.M.  |lastauthoramp=yes |journal = J. Biol. Chem. |date = 1992 |volume = 267 |pages = 13086-13092 |pmid = 1618807}}</ref><ref>{{cite journal | title = New insights into the binding mode of coenzymes: structure of ''Thermus thermophilus'' Δ<sup>1</sup>-pyrroline-5-carboxylate dehydrogenase complexed with  NADP<sup>+</sup> |author = Inagaki, E., Ohshima, N., Sakamoto, K., Babayeva, N.D., Kato, H., Yokoyama, S. and Tahirov, T.H. |journal = Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |date = 2007 |volume = 63 |pages = 462-465 |pmid = 17554163}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: (-{S}-)-1-pirolidin-5-karboksilat + -{NAD(P)}-<sup>+</sup> + 2-{H}-<sub>2</sub>O <math>\rightleftharpoons</math> -{L}--glutamat + -{NAD(P)H + H}-<sup>+</sup>

Ovaj enzim može da oksiduje brojne 1-pirolidine, e.g. 3-hidroksi-1-pirolidin-5-karboksilat se konvertuje u 4-hidroksiglutamat i (-{R}-)-1-pirolidin-5-karboksilat se konvertuje u -{D}--glutamat.

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|1-pyrroline-5-carboxylate+dehydrogenase}}

{{CH-NH oksidoreduktaze-lat}}
{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

{{normativna kontrola}}

[[Категорија:ЕЦ 1.5.1]]