Изворни код странице Žučna-kiselina 7alfa-dehidroksilaza

{{Infobox Enzim-lat
| Name = Žučna-kiselina 7alfa-dehidroksilaza
| EC_number = 1.17.99.5
| CAS_number = 
| IUBMB_EC_number = 1/17/99/5
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Žučna-kiselina 7alfa-dehidroksilaza''' ({{EC broj-lat|1.17.99.5}}, ''holatna 7alfa-dehidroksilaza'', ''7alfa-dehidroksilaza'', ''žučno kiselinska 7-dehidroksilaza'') je [[enzim]] sa sistematskim imenom ''dezoksiholat:-{NAD}-<sup>+</sup> oksidoreduktaza''.<ref>{{cite journal | title = Cofactor requirements for 7α-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, ''Eubacterium'' species V.P.I. 12708 | url = https://archive.org/details/sim_journal-of-lipid-research_1981-08_22_6/page/891 |author = White, B.A., Cacciapuoti, A.F., Fricke, R.J., Whitehead, T.R., Mosbach, E.H. and Hylemon, P.B. |journal = J. Lipid Res. |date = 1981 |volume = 22 |pmid = 7276750| pages = 891–898 }}</ref><ref>{{cite journal | title = Regulation of bile acid 7-dehydroxylase activity by NAD<small><sup>+</sup></small> and NADH in cell extracts of ''Eubacterium'' species V.P.I. 12708 | url = https://archive.org/details/sim_journal-of-lipid-research_1983-01_24_1/page/20 |author = White, B.A., Paone, D.A., Cacciapuoti, A.F., Fricke, R.J., Mosbach, E.H. and Hylemon, P.B. |journal = J. Lipid Res. |date = 1983 |volume = 24 |pmid = 6833878| pages = 20–27 }}</ref><ref>{{cite journal | title = Molecular cloning of bile acid 7-dehydroxylase from ''Eubacterium'' sp. strain VPI 12708 | url = https://archive.org/details/sim_journal-of-bacteriology_1987-04_169_4/page/1516 |author = Coleman, J.P., White, W.B. and Hylemon, P.B. |journal = J. Bacteriol. |date = 1987 |volume = 169 |pmid = 3549693| pages = 1516–1521 }}</ref><ref>{{cite journal | title = The enzymes, regulation, and genetics of bile acid synthesis | url = https://archive.org/details/sim_annual-review-of-biochemistry_2003_72/page/137 |author = Russell, D.W. |journal = Annu. Rev. Biochem. |date = 2003 |volume = 72 |pmid = 12543708| pages = 137–174 }}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: (1) dezoksiholat + -{NAD}-<sup>+</sup> + -{H}-<sub>2</sub>O <math>\rightleftharpoons</math> holat + -{NADH}- + -{H}-<sup>+</sup>
: (2) lithoholat + -{NAD}-<sup>+</sup> +-{H}-<sub>2</sub>O <math>\rightleftharpoons</math> henodezoksiholat + -{NADH}- + -{H}-<sup>+</sup>

Ovaj enzim je visoko specifičan za [[Žučna kiselina|žučno-kiselinske]] supstrate. Za njegovo dejstvo je neophodna slobodna -{C}--24 karboksilna grupa i nezaklonjena 7alfa-hidroksi grupa na B-prstenu [[steroid]] jezgra.

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|Bile-acid+7alpha-dehydroxylase}}

{{Druge oksidoreduktaze-lat}}
{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

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[[Категорија:ЕЦ 1.17.99]]