Изворни код странице (-)-Alfa-pinenska sintaza

{{Infobox Enzim-lat
| Name = (-)-Alfa-pinenska sintaza
| EC_number = 4.2.3.119
| CAS_number = 
| IUBMB_EC_number = 4/2/3/119
| GO_code = 
| image = 
| width = 
| caption =
}}
'''(-)-Alfa-pinenska sintaza''' ({{EC broj-lat|4.2.3.119}}, ''(-)-alfa-pinen/(-)-kamken sintaza'', ''(-)-alfa-pinen ciklaza'') je [[enzim]] sa sistematskim imenom ''geranil-difosfat difosfat-lijaza (ciklizacija, formira (-)-alfa-pinen)''.<ref>{{cite journal | title = Pinene cyclases I and II. Two enzymes from sage (''Salvia officinalis'') which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration |author1=Gambliel, H. |author2= Croteau, R.  |lastauthoramp=yes |journal = J. Biol. Chem. |date = 1984 |volume = 259 |pages = 740-748 |pmid = 6693393}}</ref><ref>{{cite journal | title = Isotopically sensitive branching in the formation of cyclic monoterpenes: proof that (-)-α-pinene and (-)-β-pinene are synthesized by the same monoterpene cyclase via deprotonation of a common intermediate |author = Croteau, R.B. |author2= Wheeler, C.J. |author3= Cane, D.E. |author4= Ebert, R. |author5= Ha, H.J. |lastauthoramp=yes |journal = Biochemistry |date = 1987 |volume = 26 |pages = 5383-5389 |pmid = 3314988}}</ref><ref>{{cite journal | title = Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene |author = Croteau, R. |author2= Satterwhite, D.M. |author3= Cane, D.E. |author4= Chang, C.C. |lastauthoramp=yes|journal = J. Biol. Chem. |date = 1988 |volume = 263 |pages = 10063-10071 |pmid = 3392006}}</ref><ref>{{cite journal | title = Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage |author1=Croteau, R.  |author2=Satterwhite, D.M.  |lastauthoramp=yes |journal = J. Biol. Chem. |date = 1989 |volume = 264 |pages = 15309-15315 |pmid = 2768265}}</ref><ref>{{cite journal | title = Stereochemistry of the proton elimination in the formation of (+)- and (-)-α-pinene by monoterpene cyclases from sage (''Salvia officinalis'') |author = Pyun, H.J. |author2= Wagschal, K.C. |author3= Jung, D.I. |author4= Coates, R.M. |author5= Croteau, R. |lastauthoramp=yes |journal = Arch. Biochem. Biophys. |date = 1994 |volume = 308 |pages = 488-496 |pmid = 8109979}}</ref><ref>{{cite journal | title = Cloning and functional characterization of a β-pinene synthase from ''Artemisia annua'' that shows a circadian pattern of expression | url = https://archive.org/details/sim_plant-physiology_2002-09_130_1/page/477 |author = Lu, S. |author2= Xu, R. |author3= Jia, J.W. |author4= Pang, J. |author5= Matsuda, S.P. |author6= Chen, X.Y. |journal = Plant Physiol. |date = 2002 |volume = 130 |pages = 477-486 |pmid = 12226526}}</ref><ref>{{cite journal | title = Wound-inducible pinene cyclase from grand fir: purification, characterization, and renaturation after SDS-PAGE |author = Lewinsohn, E. |author2= Gijzen, M. |author3= Croteau, R. |lastauthoramp=yes|journal = Arch. Biochem. Biophys. |date = 1992 |volume = 293 |pages = 167-173 |pmid = 1731633}}</ref><ref>{{cite journal | title = Monoterpene synthases from grand fir (''Abies grandis''). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4''S'')-limonene synthase, and (-)-(1''S'',5''S'')-pinene synthase |author = Bohlmann, J. |author2= Steele, C.L. |author3= Croteau, R. |lastauthoramp=yes|journal = J. Biol. Chem. |date = 1997 |volume = 272 |pages = 21784-21792 |pmid = 9268308}}</ref><ref>{{cite journal | title = cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the ''Tpsd'' gene family from grand fir (''Abies grandis'') |author = Bohlmann, J. |author2= Phillips, M. |author3= Ramachandiran, V. |author4= Katoh, S. |author5= Croteau, R. |lastauthoramp=yes|journal = Arch. Biochem. Biophys. |date = 1999 |volume = 368 |pages = 232-243 |pmid = 10441373}}</ref><ref>{{cite journal | title = Mutational analysis of a monoterpene synthase reaction: altered catalysis through directed mutagenesis of (-)-pinene synthase from ''Abies grandis'' |author1=Hyatt, D.C.  |author2=Croteau, R.  |lastauthoramp=yes |journal = Arch. Biochem. Biophys. |date = 2005 |volume = 439 |pages = 222-233 |pmid = 15978541}}</ref><ref>{{cite journal | title = Monoterpene synthases of loblolly pine (''Pinus taeda'') produce pinene isomers and enantiomers |author = Phillips, M.A. |author2= Savage, T.J. |author3= Croteau, R. |lastauthoramp=yes |journal = Arch. Biochem. Biophys. |date = 1999 |volume = 372 |pages = 197-204 |pmid = 10562434}}</ref><ref>{{cite journal | title = cDNA isolation, functional expression, and characterization of (+)-α-pinene synthase and (-)-α-pinene synthase from loblolly pine (''Pinus taeda''): stereocontrol in pinene biosynthesis |author = Phillips, M.A. |author2= Wildung, M.R. |author3= Williams, D.C. |author4= Hyatt, D.C. |author5= Croteau, R. |lastauthoramp=yes|journal = Arch. Biochem. Biophys. |date = 2003 |volume = 411 |pages = 267-276 |pmid = 12623076}}</ref><ref>{{cite journal | title = Insect attack and wounding induce traumatic resin duct development and gene expression of (-)-pinene synthase in Sitka spruce | url = https://archive.org/details/sim_plant-physiology_2003-09_133_1/page/368 |author = McKay, S.A. |author2= Hunter, W.L. |author3= Godard, K.A. |author4= Wang, S.X. |author5= Martin, D.M. |author6= Bohlmann, J. |author7= Plant, A.L. |lastauthoramp=yes|journal = Plant Physiol. |date = 2003 |volume = 133 |pages = 368-378 |pmid = 12970502}}</ref><ref>{{cite journal | title = Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, ''Pseudotsuga menziesii'' | url = https://archive.org/details/sim_phytochemistry_2005-06_66_12/page/1427 |author= Huber, D.P.W. |author2= Philippe, R.N. |author3= Godard, K.-A. |author4= Sturrock, R.N. |author5= Bohlmann, J. |lastauthoramp=yes|journal = Phytochemistry |date = 2005 |volume = 66 |pages = 1427-1439 |pmid = 15921711}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]]

: geranil difosfat <math>\rightleftharpoons</math> (-)-alfa-pinen + [[pirofosfat|difosfat]]

Ciklaza II iz -{''[[Жалфија|Salvia officinalis]]''}- formira jednake količine (-)-alfa-pinena, (-)-beta-pinena i (-)-kamfena.

== Reference ==
{{reflist}}

== Literatura ==
{{Литература}}
* {{PriceEnzymology3rd}}
* {{TooneAdvancesInEnzymology}}
* {{Branden ProteinStructure2nd}}
* {{SegelEnzymeKinetics}}
* {{JencksCatalysisInChemistryAndEnzymology}}
{{Литература крај}}
== Spoljašnje veze ==
* {{MeshName|(-)-alpha-pinene+synthase}}

{{Ugljenično-kiseonične lijaze-lat}}
{{Enzimi-lat}}
{{Portal bar-lat|Molekularna i ćelijska biologija|Hemija}}

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[[Категорија:ЕЦ 4.2.3]]